Compare care options for Major Depressive Disorder

See what we know about each option. We may not have all options. This page does not pick one for you.

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3 selected

What we found

Each option is for Major Depressive Disorder. Research and local care are different facts.

Sertraline

What it is

We have not added a short description yet.

Why it is on this page

People: source-defined population

DailyMed sertraline (Zoloft) label · checked Sep 20, 2026

Relationship: label-reported clinical studies for the Need

Scope: country:US

Pointer: /sections/1

Supporting passage: The efficacy of ZOLOFT as a treatment for MDD was established in two randomized, double-blind, placebo-controlled studies and one double-blind, randomized-withdrawal study following an open label study in adult (ages 18 to 65) outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for MDD (studies MDD-1 and MDD-2).

Open source

Source: DailyMed sertraline (Zoloft) label. Checked Sep 20, 2026. Scope: country:US. Link: https://dailymed.nlm.nih.gov/dailymed/services/v2/spls/fda754f6-d0f3-4dce-a17a-927d64f912f7.xml

Research for Major Depressive Disorder

Research suggests benefit in this exact scope

Published Sep 20, 2026 · revision 1

conclusion

The current ZOLOFT label reports randomized, double-blind, placebo-controlled studies supporting its MDD evidence scope. This bounded assessment does not compare every option or determine personal suitability.

DailyMed sertraline (Zoloft) label · checked Sep 20, 2026

Relationship: supports bounded conclusion

Scope: country:US

Pointer: /sections/1

Supporting passage: The efficacy of ZOLOFT as a treatment for MDD was established in two randomized, double-blind, placebo-controlled studies and one double-blind, randomized-withdrawal study following an open label study in adult (ages 18 to 65) outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for MDD (studies MDD-1 and MDD-2).

Open source

Source: DailyMed sertraline (Zoloft) label. Checked Sep 20, 2026. Scope: country:US. Link: https://dailymed.nlm.nih.gov/dailymed/services/v2/spls/fda754f6-d0f3-4dce-a17a-927d64f912f7.xml

Compared with the others: Not directly compared. We show each option’s own research.

See the researchFind care

Cognitive Behavioral Therapy

What it is

We have not added a short description yet.

Why it is on this page

People: source-defined population

NIMH Depression · checked Sep 20, 2026

Relationship: source-described CBT relationship for the Need

Scope: need:major-depressive-disorder

Pointer: /publication/treatmentExcerpt

Open source

Source: NIMH Depression. Checked Sep 20, 2026. Scope: need:major-depressive-disorder. Link: https://www.nimh.nih.gov/health/publications/depression

Research for Major Depressive Disorder

Research suggests benefit in this exact scope

Published Sep 20, 2026 · revision 1

conclusion

NIMH identifies cognitive behavioral therapy as an evidence-based therapy for depression. This bounded assessment does not compare every option or determine personal suitability.

NIMH Depression · checked Sep 20, 2026

Relationship: supports bounded conclusion

Scope: need:major-depressive-disorder

Pointer: /publication/treatmentExcerpt

Open source

Source: NIMH Depression. Checked Sep 20, 2026. Scope: need:major-depressive-disorder. Link: https://www.nimh.nih.gov/health/publications/depression

Compared with the others: Not directly compared. We show each option’s own research.

See the researchFind care

Fluoxetine

What it is

We have not added a short description yet.

Why it is on this page

People: source-defined study populations

DailyMed fluoxetine hydrochloride label · checked Sep 19, 2026

Relationship: label-reported clinical studies for the Need

Scope: country:US

Pointer: /sections/4

Supporting passage: The efficacy of fluoxetine was studied in 5- and 6-week placebo-controlled trials with depressed adult and geriatric outpatients (≥ 18 years of age) whose diagnoses corresponded most closely to the DSM-III (currently DSM-IV) category of MDD.

Open source

Source: DailyMed fluoxetine hydrochloride label. Checked Sep 19, 2026. Scope: country:US. Link: https://dailymed.nlm.nih.gov/dailymed/services/v2/spls/f274f102-67ec-46e7-b248-533be2e3003b.xml

Research for Major Depressive Disorder

Research suggests benefit in this exact scope

Published Sep 20, 2026 · revision 1

conclusion

The retained fluoxetine label reports placebo-controlled studies for major depressive disorder; this assessment does not determine personal suitability or compare fluoxetine with every alternative.

DailyMed fluoxetine hydrochloride label · checked Sep 19, 2026

Relationship: supports bounded conclusion

Scope: country:US

Pointer: /sections/4

Supporting passage: The efficacy of fluoxetine was studied in 5- and 6-week placebo-controlled trials with depressed adult and geriatric outpatients (≥ 18 years of age) whose diagnoses corresponded most closely to the DSM-III (currently DSM-IV) category of MDD.

Open source

Source: DailyMed fluoxetine hydrochloride label. Checked Sep 19, 2026. Scope: country:US. Link: https://dailymed.nlm.nih.gov/dailymed/services/v2/spls/f274f102-67ec-46e7-b248-533be2e3003b.xml

Compared with the others: Not directly compared. We show each option’s own research.

See the researchFind care

Page link: https://everyoption.org/compare/major-depressive-disorder?treatments=sertraline%2Ccognitive-behavioral-therapy%2Cfluoxetine