People: patients with Obsessive-Compulsive Disorder whose obsessions or compulsions cause marked distress, are time-consuming, or significantly interfere with social or occupational functioning (DSM-III-R); labeled effectiveness data include adults and children and adolescents 10 to 17 years of age
DailyMed clomipramine (Anafranil) label · checked Oct 16, 2026
Relationship: labeled indication
Statement scope
Formulation or format
capsule
Indication
treatment of obsessions and compulsions in Obsessive-Compulsive Disorder (OCD)
Labeler
SpecGx LLC
Population
patients with Obsessive-Compulsive Disorder whose obsessions or compulsions cause marked distress, are time-consuming, or significantly interfere with social or occupational functioning (DSM-III-R); labeled effectiveness data include adults and children and adolescents 10 to 17 years of age
Product
ANAFRANIL (clomipramine hydrochloride) capsule
Section code
34067-9
Source collection coverage: country:US
Pointer: /sections/0
Supporting passage: Anafranil ™ (clomipramine hydrochloride) Capsules USP is indicated for the treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder (OCD).
Exposure and response prevention (ERP) is a form of CBT that NICE includes among treatment options for adults with OCD, within the scope of its guideline recommendation.
Official guideline documents · checked Aug 24, 2026
Relationship: supports
Statement scope
Document
CG31
Jurisdiction
United Kingdom
Population
adults with OCD
Source collection coverage: global
Pointer: /document/recommendation
Source: Official guideline documents. Checked Aug 24, 2026. Scope: global.
Why it is on this page
People: niños y adolescentes con TOC
GuíaSalud GPC 634: TOC en niños y adolescentes · checked Oct 16, 2026
Relationship: recomendado para población pediátrica con TOC
Source: GuíaSalud GPC 634: TOC en niños y adolescentes. Checked Oct 16, 2026. Scope: country:ES. Link: https://portal.guiasalud.es/wp-content/uploads/2025/02/gpc_634_toc_nino_adolescente_compl.pdf
Why it is on this page
People: adults with OCD
Official guideline documents · checked Aug 24, 2026
Relationship: guideline recommendation
Statement scope
Document
CG31
Jurisdiction
United Kingdom
Population
adults with OCD
Source collection coverage: global
Pointer: /document/recommendation
Source: Official guideline documents. Checked Aug 24, 2026. Scope: global.
Research for Obsessive-Compulsive Disorder
Research suggests benefit in this exact scope
Published Oct 7, 2026 · revision 4
What research says
NICE CG31, recommendation 1.5.1.1, identifies psychological treatment that includes ERP as a low-intensity initial option for adults with OCD when impairment in everyday functioning is mild, when they prefer a low-intensity approach, or both. This is an attributed guideline recommendation for that adult group.
Official guideline documents · checked Oct 3, 2026
Relationship: supports the attributed adult initial-treatment recommendation and its delivery qualifiers
Statement scope
Formulation or format
brief individual cognitive behavioural therapy (CBT; including ERP) using structured self‑help materials; brief individual CBT (including ERP) by telephone; group CBT (including ERP)
Guideline
CG31
Indication
obsessive-compulsive disorder
Intensity
up to 10 therapist hours per patient; group CBT (including ERP) may exceed 10 hours
Treatment phase
initial treatment
Population
Adults with OCD whose functional impairment is mild and/or who prefer a low-intensity approach
Source: Official guideline documents. Checked Oct 3, 2026. Scope: global. Link: https://www.nice.org.uk/guidance/cg31/chapter/Recommendations
Delivery and time commitment
For this initial-treatment pathway, NICE CG31 describes low-intensity care as using up to 10 hours of therapist time per patient. Its listed formats include brief individual CBT with ERP supported by structured self-help materials, brief individual CBT with ERP by telephone, and group CBT with ERP. In the group format, a patient may receive more than 10 hours of therapy.
Official guideline documents · checked Oct 3, 2026
Relationship: supports the attributed adult initial-treatment recommendation and its delivery qualifiers
Statement scope
Formulation or format
brief individual cognitive behavioural therapy (CBT; including ERP) using structured self‑help materials; brief individual CBT (including ERP) by telephone; group CBT (including ERP)
Guideline
CG31
Indication
obsessive-compulsive disorder
Intensity
up to 10 therapist hours per patient; group CBT (including ERP) may exceed 10 hours
Treatment phase
initial treatment
Population
Adults with OCD whose functional impairment is mild and/or who prefer a low-intensity approach
Source: Official guideline documents. Checked Oct 3, 2026. Scope: global. Link: https://www.nice.org.uk/guidance/cg31/chapter/Recommendations
More intensive option
For adults with OCD whose day-to-day functioning is moderately impaired, England’s NICE guideline CG31 (recommendation 1.5.1.3) says they should be offered a choice between a course of an SSRI medicine and more intensive CBT that includes ERP, meaning more than 10 hours of therapist time, because the two appear to be comparably effective. This describes a guideline pathway; a local provider’s approach and an individual’s needs may differ.
Official guideline documents · checked Oct 7, 2026
Relationship: supports the attributed moderate-impairment choice and intensive therapist time
Statement scope
Alternative
a course of an SSRI
Delivery
more intensive CBT (including ERP; more than 10 therapist hours per patient)
Guideline
CG31
Indication
Obsessive-compulsive disorder
Population
Adults with OCD with moderate functional impairment covered by NICE CG31
Source: Official guideline documents. Checked Oct 7, 2026. Scope: global. Link: https://www.nice.org.uk/guidance/cg31/chapter/Recommendations
Severe impairment option
For adults with OCD whose day-to-day functioning is severely impaired, England’s NICE guideline CG31 (recommendation 1.5.1.4) says they should be offered combined treatment: an SSRI medicine together with CBT that includes ERP. This describes a guideline pathway; a local provider’s approach and an individual’s needs may differ.
Official guideline documents · checked Oct 7, 2026
Relationship: supports the attributed severe-impairment combined treatment
Statement scope
Delivery
combined treatment with an SSRI and CBT (including ERP)
Source: Official guideline documents. Checked Oct 7, 2026. Scope: global. Link: https://www.nice.org.uk/guidance/cg31/chapter/Recommendations
Children and young people
For children and young people with OCD whose functioning is moderately to severely impaired, or mildly impaired when guided self-help has not worked or was declined, NICE CG31 (recommendation 1.5.1.9) names CBT that includes ERP as the treatment of choice, involving the family or carers and adapted to the child’s developmental age. This describes a guideline pathway in England; a local provider’s approach and an individual’s needs may differ.
Official guideline documents · checked Oct 7, 2026
Relationship: supports the attributed young-people treatment of choice and its family and age adaptations
Statement scope
Delivery
CBT (including ERP) that involves the family or carers and is adapted to suit the developmental age of the child
Format
Group or individual formats depending upon the preference of the child or young person and their family or carers
Guideline
CG31
Indication
OCD
Issuer
National Institute for Health and Care Excellence
Population
Children and young people with OCD with moderate to severe functional impairment, and those with OCD with mild functional impairment for whom guided self-help has been ineffective or refused
Recommendation
1.5.1.9
Section
1.5.1 Initial treatment options: Children and young people