Sertraline for Major Depressive Disorder
Published assessmentPublished Sep 20, 2026 · revision 1
Learn what this care may do. See what research says. Then check where to get care. A place may not be taking new patients.
See published Need usesSertraline (brand name ZOLOFT) is a prescription medicine. Its U.S. product labeling lists obsessive-compulsive disorder (OCD) among the conditions it is indicated to treat.
Relationship: supports
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open sourceEveryOption includes sertraline for OCD because the DailyMed ZOLOFT label’s Indications and Usage section names OCD as a labeled indication. That label statement was checked against this source. A clinical evidence assessment of how well sertraline works for OCD has not yet been published here.
Relationship: supports
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open source• Obsessive-compulsive disorder (OCD)
Relationship: supports
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open sourceThis page explains why the option appears and what the cited label supports. It does not set dosing, compare treatments, or report availability. Access information is not shown here.
Relationship: supports
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open sourceCited source: DailyMed (U.S. National Library of Medicine) structured product label for ZOLOFT (sertraline hydrochloride), SET ID fda754f6-d0f3-4dce-a17a-927d64f912f7, version 7, Indications and Usage. Hosting on DailyMed is not a license to republish the full label.
Relationship: supports
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open sourceEveryOption currently publishes Sertraline research for bulimia nervosa, major depressive disorder, obsessive-compulsive disorder, and panic disorder. Each exact Need page states its source and limits. This is not a complete list of uses.
Relationship: supports published treatment scope
Statement scope
Not assessed
bulimia nervosa
outpatients with bulimia nervosa as described by the evidence review
Source collection coverage: global
Pointer: /document/passage
Open sourceRelationship: supports published treatment scope
Statement scope
Not assessed
Panic Disorder
source-defined population
Source collection coverage: country:US
Pointer: /sections/2
Supporting passage: The effectiveness of ZOLOFT in the treatment of PD was demonstrated in three double‑blind, placebo‑controlled studies (Studies PD-1, PD-2, and PD‑3) of adult outpatients who had a primary diagnosis of PD (DSM‑III‑R), with or without agoraphobia.
Open sourceRelationship: supports published treatment scope
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open sourceRelationship: supports published treatment scope
Statement scope
Not assessed
Major Depressive Disorder
source-defined population
Source collection coverage: country:US
Pointer: /sections/1
Supporting passage: The efficacy of ZOLOFT as a treatment for MDD was established in two randomized, double-blind, placebo-controlled studies and one double-blind, randomized-withdrawal study following an open label study in adult (ages 18 to 65) outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for MDD (studies MDD-1 and MDD-2).
Open sourceSelect an exact Need to inspect its scoped research. These are the uses currently published on EveryOption; they do not establish every use of Sertraline or a personal recommendation.
Published assessmentPublished Sep 20, 2026 · revision 1
Published assessmentPublished Sep 20, 2026 · revision 1
Published assessmentPublished Sep 21, 2026 · revision 1
Not reviewed
The research answer belongs to this exact Need and its published scope. It does not establish benefit for other uses of Sertraline.
Research suggests benefit in this exact scope
Published Sep 20, 2026 · revision 1
The current ZOLOFT label reports randomized, double-blind, placebo-controlled studies supporting its MDD evidence scope. This bounded assessment does not compare every option or determine personal suitability.
Relationship: supports bounded conclusion
Statement scope
Not assessed
Major Depressive Disorder
source-defined population
Source collection coverage: country:US
Pointer: /sections/1
Supporting passage: The efficacy of ZOLOFT as a treatment for MDD was established in two randomized, double-blind, placebo-controlled studies and one double-blind, randomized-withdrawal study following an open label study in adult (ages 18 to 65) outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for MDD (studies MDD-1 and MDD-2).
Open sourceRelationship: label-reported clinical studies for the Need
Statement scope
Not assessed
Major Depressive Disorder
source-defined population
Source collection coverage: country:US
Pointer: /sections/1
Supporting passage: The efficacy of ZOLOFT as a treatment for MDD was established in two randomized, double-blind, placebo-controlled studies and one double-blind, randomized-withdrawal study following an open label study in adult (ages 18 to 65) outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for MDD (studies MDD-1 and MDD-2).
Open sourceThe research answer belongs to this exact Need and its published scope. It does not establish benefit for other uses of Sertraline.
Research suggests benefit in this exact scope
Published Sep 20, 2026 · revision 1
The current ZOLOFT label reports three double-blind, placebo-controlled studies in adult outpatients with panic disorder. This bounded assessment does not compare every option or determine personal suitability.
Relationship: supports bounded conclusion
Statement scope
Not assessed
Panic Disorder
source-defined population
Source collection coverage: country:US
Pointer: /sections/2
Supporting passage: The effectiveness of ZOLOFT in the treatment of PD was demonstrated in three double‑blind, placebo‑controlled studies (Studies PD-1, PD-2, and PD‑3) of adult outpatients who had a primary diagnosis of PD (DSM‑III‑R), with or without agoraphobia.
Open sourceRelationship: label-reported clinical studies for the Need
Statement scope
Not assessed
Panic Disorder
source-defined population
Source collection coverage: country:US
Pointer: /sections/2
Supporting passage: The effectiveness of ZOLOFT in the treatment of PD was demonstrated in three double‑blind, placebo‑controlled studies (Studies PD-1, PD-2, and PD‑3) of adult outpatients who had a primary diagnosis of PD (DSM‑III‑R), with or without agoraphobia.
Open sourceThe research answer belongs to this exact Need and its published scope. It does not establish benefit for other uses of Sertraline.
Promising, with important evidence limits
Published Sep 21, 2026 · revision 1
An open-access evidence review reports one 12-week placebo-controlled study in outpatients with bulimia nervosa that found fewer binge-eating crises and purging episodes with sertraline; one older study is promising but limited evidence. This assessment does not compare every option or determine personal suitability.
Relationship: supports bounded conclusion
Statement scope
Not assessed
bulimia nervosa
outpatients with bulimia nervosa as described by the evidence review
Source collection coverage: global
Pointer: /document/passage
Open sourceRelationship: small trial of sertraline for bulimia nervosa
Statement scope
Not assessed
bulimia nervosa
outpatients with bulimia nervosa as described by the evidence review
Source collection coverage: global
Pointer: /document/passage
Open sourceThe research answer belongs to this exact Need and its published scope. It does not establish benefit for other uses of Sertraline.
Not reviewed. No current published assessment exists for this exact Treatment and Need. This does not establish benefit or no benefit.
Relationship: labeled indication
Statement scope
tablet, film coated; oral solution
obsessive-compulsive disorder
patients with obsessive-compulsive disorder as labeled
34067-9
Source collection coverage: country:US
Pointer: /sections/1
Open sourceResearch and local availability are different facts. Add a place to see known, source-backed access options for Sertraline.
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